A Genetic Clog in the Vitamin A Transport Machinery
نویسندگان
چکیده
Chou et al. discover a new mode of maternal inheritance by analyzing human mutations in plasma retinol binding protein (RBP). Mechanistically, these mutations simultaneously lower RBP's affinity for vitamin A and greatly increase its affinity for its cell-surface receptor, thus dominantly blocking the transmembrane transport of vitamin A.
منابع مشابه
Bedload transport predictions based on field measurement data by combination of artificial neural network and genetic programming
Bedload transport is an essential component of river dynamics and estimation of its rate is important to many aspects of river management. In this study, measured bedload by Helley- Smith sampler was used to estimate the bedload transport of Kurau River in Malaysia. An artificial neural network, genetic programming and a combination of genetic programming and a neural network were used to estim...
متن کاملBedload transport predictions based on field measurement data by combination of artificial neural network and genetic programming
Bedload transport is an essential component of river dynamics and estimation of its rate is important to many aspects of river management. In this study, measured bedload by Helley- Smith sampler was used to estimate the bedload transport of Kurau River in Malaysia. An artificial neural network, genetic programming and a combination of genetic programming and a neural network were used to estim...
متن کاملA review on the relation between obesity and vitamin D with pediatric asthma, and a report of a pilot study in Tehran, Iran: review article
Asthma is an inflammatory and chronic disease that affects about 300 million people globally. The disease is more common in developed countries. The increase in the prevalence of asthma is not only due to genetic factors, but also to many environmental factors related to urbanization and type of nutrition. It has been reported that obesity is an independent risk factor for asthma and obese chil...
متن کاملEvaluation of vitamins diversity produced by probiotics in the microbiome and introduction of selected species
Vitamins are important micronutrients and are often precursors of enzymes that living cells need to perform biochemical reactions. Because humans cannot biosynthesize most vitamins, therefore, they must be obtained exogenously. Although a variety of vitamins are found in most foods, many people's vitamin deficiencies still occur mainly due to malnutrition as a result of inadequate food consumpt...
متن کاملVitamin D and the urgency of paying attention to this vital element in the body
Vitamin D is a vital element in the body that plays an important role in the growth and strength of muscles and bones by its effect on calcium absorption from the intestine. Vitamin D biosynthesis begins with the exposure to UV of sunlight from the skin. Cholecalciferol transfers from the skin and the intestine to the liver, and then binds to the DBP protein and eventually enters the kidney to...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Cell
دوره 161 شماره
صفحات -
تاریخ انتشار 2015